癌变·畸变·突变 ›› 2000, Vol. 12 ›› Issue (1): 39-041.doi: 10.3969/j.issn.1004-616x.2000.01.012

• 论著 • 上一篇    下一篇

亚硒酸钠拮抗烹调色拉油烟冷凝物致小鼠毒性作用的研究

周纯先,肖 棣,王帮霞   

  1. 蚌埠医学院卫生学教研室,安徽蚌埠 233003
  • 收稿日期:1999-02-07 修回日期:1999-07-04 出版日期:2000-01-30 发布日期:2000-01-30

ANTAGONISTIC EFECTS OF SODIUM SELENITE ON TOXICITY OF SALAD OIL VAPOR CONDENSATE IN MICE

ZHOU Chun-xian , XIAO Di , WANG Bang-xia   

  1. Department of Public Health, Bengbu Medical College, Anhui Bengbu  233003, China
  • Received:1999-02-07 Revised:1999-07-04 Online:2000-01-30 Published:2000-01-30

摘要: 目的:实验观察亚硒酸钠对色拉油烟冷凝物致小鼠毒性作用的影响。方法:采用微核试验和精子畸形分析方法,对亚硒酸钠拮抗烹调色拉油烟冷凝物致小鼠微核率和精子畸形率的作用进行了实验观察。试验资料采用U 检验分析。结果:小鼠灌胃给予烹调色拉油烟冷凝物5ml/ kg 和10ml/ kg 体重15d 后,其微核率和精子畸形率显著地高于2. 5ml/ kg 组和单纯色拉油对照组( P < 0. 01) ,而2. 5ml/ kg 组上述两项指标与对照组差异无显著性( P > 0. 05) 。结果还显示,若同时给小鼠补充亚硒酸钠1. 0mg/ kg 体重后,可使烹调色拉油烟冷凝物(5ml/ kg 体重) 致小鼠微核率和精子畸形率的作用明显减弱。结论:烹调色拉油烟冷凝物对小鼠具有明显地毒性作用,而补充亚硒酸钠则可降低其作用。

关键词: 亚硒酸钠, 色拉油烟冷凝物, 毒性作用, 小鼠

Abstract: Purpose : To study the effect of sodium selenite on the toxicity of salad oil vapor condensate in mice.Methods : The antagonistic effect s of sodium selenite on the rate of micronucleus and of sperm deformity in mice were abserved with the microunucles test and the sperm deformity analysis. The experimental data were calculated by statistical in U test . Results : The rate of micronucleus and of sperm deformity of mice t reated with salad oil vapor condensate at 5ml/ kg and 10ml/ kg groups was abviously higher than that of 2. 5ml/ kg and conevol groups ( P < 0. 01) . After the mice were suplied sodinm selenite at 1. 0mg/ kg , the rate of micronucleus and of sperm deformity was significantly lower than that of salad oil vapor condensate group ( P < 0. 01) . Conclusion :The antagonistic effect s of sodium selenite on the toxicity of salad oil vapor condensate was significant in mice.

Key words: sodium selenite, salad oil vapor condensate, toxicity effect s, mice

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